Acute impact of transcatheter edge-to-edge repair for mitral regurgitation on left ventricular function

Abstract Introduction Transcatheter Edge-to-Edge repair (TEER) for the therapy of mitral valve regurgitation (MR) is an alternative to surgery high risk patients. It a minimal invasive procedure but acute impact pre- and afterload decrease, due reduction both MR area (MVA), on left ventricle (LV) systolic function was never formally evaluated. Method Fifty patients with mixed etiologies from our TEER register complete 3D datasets LV before after were included in this study. volumes function, as evaluate by ejection fraction (LVEF), global longitudinal strain (LV-GLS) circumferential (LV-GCS), (3D vena contracta area, VCA) evaluated at end therapy. Results The majority suffered secondary (54%), one device implanted 64% two 36% population. leads significant all volume parameters excepted end-diastolic which increased non-significantly (Table 1). decrease LVEF linked GLS GCS multivariate analysis (r 0.85), having higher influence (beta −0.606 vs −0.435). In univariate linear analysis, LVEF, inverse proportional direct VCA. also directly MVA percental reduction. After evaluation, kept VCA (r=0.51, p=0.001), only (r=0.371, P=0.08) diminution (r=0.313, p=0.027). Conclusion TEER, ventricular seems principally increase (i.e. reduction); ventricles highest fractions being apparently maximally impacted. Funding Acknowledgement Type funding sources: None.